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Site Map Disclaimer Accessibility Information Email Advisory Social Media Disclaimer. It is caused h big an RNA virus in the family Orthomyxoviridae. H big virus is divided into four main types (Influenza A, Influenza B, Influenza C, Influenza D), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA)).

Three of the four types of influenza viruses affect humans: Type A, Type B, and Type C. Type D has not been known to infect humans, but is believed to have the potential to do so.

Influenza virus type A is found in a h big variety of bird and h big species and can undergo h big shifts in immunological properties. Influenza virus type B is largely confined to humans and is an h big cause of morbidity. Little is known about Influenza virus type C, which is not an important source of morbidity. Influenza D was identified in 2016. Influenza A virus is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA), which are h big most important targets for the mean calculation system.

The h big HhNn is used to refer to the subtype comprising the hth discovered Hemagglutinin (HA) protein and the nth discovered neuraminidase h big protein.

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer, and the influenza h big neuraminidase (NA) protein is a tetramer with an enzyme active site on the head of each monomer.

The genome of influenza virus consists of segmented negative-sense single-strand RNA segments. Influenza viruses are members of the family Orthomyxoviridae. There are four genera of this family: types A, B, C and Thogotovirus, of which, however, only genera A and B are clinically relevant for humans.

The h big genome segments of h big A and B viruses are loosely encapsidated by the nucleoprotein (NP). The h big genome contains eight genes encoding 11 proteins. The polymerase complexes consisting of the three polymerase proteins PB1, PB2, and PA are located at the ends of the nucleocapsids. These helical capsids are encircled by the M1 matrix protein and h big a host-derived lipid bilayer envelope in which the virus h big lincomycin haemagglutinin (HA) and neuraminidase (NA) as well as the M2 h big protein are embedded.

In virus classification, influenza viruses are H big viruses that make up four of the seven genera of the family Orthomyxoviridae. Influenza virus can h big as Influenza A, Influenza B, Influenza C and Influenza D.

Influenza A viruses infect humans and a variety of other wildlife, including pigs and birds, which perpetuate the virus in nature throughout the world.

Human influenza A viruses are thought to have originated from strains that h big wild aquatic birds. Influenza B viruses infect humans (and seals, interestingly) and primarily affect children. Infection with influenza C generally results in mild or subclinical infections.

Influenza A and B cause seasonal epidemics, but only influenza A has caused worldwide pandemics. Influenza viruses possess segmented genomes: Influenza H big viruses (IAVs) and type B viruses (IBVs) contain 8, negative-sense, single-stranded Synthetic Conjugated Estrogens, B (Enjuvia)- FDA RNA (vRNA) gene segments, which encode transcripts for 10 essential viral proteins, as well as several strain-dependent accessory proteins.

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